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The impact of energy deprivation on the signaling pathways of erythrocytes was later disclosed in a mechanistic study: here, the authors demonstrated that removal of extracellular glucose and blockade of glycolysis by 2-deoxyglucose leads to fast depletion of cellular ATP

Risks are real (injection site reactions, effects on endogenous hormone production, impact on glucose control with GH secretagogues), which is why we run labs and follow up